Quantification of the Spatial Organization of the Nuclear Lamina as a Tool for Cell Classification

Figure 4

Normalized curvature and intensity measurements for a variety of cell populations are summarized. LMNA redistributes for aging and senescence, this is associated with a decrease in normalized intensity. Apoptotic cells undergo a severe morphological change, which is reflected in the increased curvature values. Apoptosis can be achieved either directly from healthy states or indirectly from old or senescent cells, adapted from [15].