Endothelin-1 Enriched Tumor Phenotype Predicts Breast Cancer Recurrence

Table 2

Multivariable Cox proportional hazard model for DFS: adjusted hazard ratios (HRs) according to age, and nodal stage, ER and HER2 status.

Variable	Adjusted HR	95% CI	𝑃-value
Age (per each year)	0.99	0.95–1.03	0.68
Nodal stage			<0.01
0 versus 2-3	0.19	0.06–0.56
1 versus 2-3	0.18	0.04–0.93
ER negative versus positive	4.05	1.53–10.72	<0.01
HER2 negative versus positive	0.67	0.24–2.08	0.49
ET-1 non-enriched versus ET-1 enriched	0.16	0.03–0.77	0.02