Synergistic Radioprotection by Gamma-Tocotrienol and Pentoxifylline: Role of cAMP Signaling
Figure 6
Effect of 200 mg/kg GT3 plus 100 mg/kg of PTX combination on serum cytokines. Among 21 cytokines analyzed in the serum samples, (a) interleukin 6 (IL-6), (b) granulocyte colony-stimulating factor (G-CSF), (c) keratinocyte chemoattractant (KC), and (d) tumor necrosis factor α (TNF-α) levels were altered in GT3 and GT3-PTX-treated groups. High levels of G-CSF, IL-6, and KC were observed with GT3 and GT3-PTX treatment (). GT3-PTX combination synergistically decreased the levels of TNF-α by 3-fold compared to vehicle ().
