Synergistic Radioprotection by Gamma-Tocotrienol and Pentoxifylline: Role of cAMP Signaling

Figure 8

Effect of mevalonate and calmodulin on radioprotection by the GT3-PTX combination. Postirradiation survival study was conducted in mice (𝑛=16) treated with GT3, GT3-PTX, GT3-PTX-mevalonate, or GT3-PTX-calmodulin. (a) shows % survival over 30 days in mice treated with 200 mg/kg of GT3 (−24 h), 200 mg/kg of PTX (−15 min) with and without 30 mg/kg of mevalonate (−24 h). (b) shows % survival over 30 days in mice treated with 200 mg/kg of GT3 (−24 h), 200 mg/kg of PTX (−15 min) with and without 2000  μ/kg of calmodulin (−15 min). Calmodulin reduced the % survival (𝑃=0.034) when given in combination with GT3 and PTX. (c) shows the histogram of % survival in various treatment groups at the end of 30 days.

(a)

(b)

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