Clinical Study
Changes in Plasma Ghrelin and Serum Leptin Levels after Cisplatin-Based Transcatheter Arterial Infusion Chemotherapy for Hepatocellular Carcinoma
Table 3
The levels of leptin and cytokines.
| | | Before | Day 1 | Day 7 | Day 14 |
| | Leptin (ng/mL) | 4.6 ± 5.1 | 20.9 ± 13.8* | 7.1 ± 8.4 | 5.2 ± 4.9 | | IL-1β (pg/mL) | 1.5 ± 1.7 | 1.7 ± 2.7 | 1.5 ± 1.3 | 1.1 ± 1.2 | | IL-1Ra (pg/mL) | 325.6 ± 383.8 | 371.9 ± 210.4 | 268.9 ± 275.5 | 415.0 ± 460.7 | | IL-2 (pg/mL) | 21.7 ± 16.6 | 18.2 ± 18.6 | 26.9 ± 18.8 | 22.1 ± 23.9 | | IL-4 (pg/mL) | 0.4 ± 0.5 | — | 0.4 ± 0.3 | 0.3 ± 0.3 | | IL-5 (pg/mL) | 1.2 ± 0.9 | 102.2 ± 204.0 | 2.8 ± 3.9 | 1.1 ± 0.6 | | IL-6 (pg/mL) | 12.5 ± 21.7 | 86.1 ± 116.4 | 18.4 ± 14.1 | 40.6 ± 96.7 | | IL-7 (pg/mL) | 3.2 ± 3.3 | 1.8 ± 0.9 | 2.9 ± 2.3 | 2.9 ± 3.3 | | IL-8 (pg/mL) | 18.9 ± 22.3 | 33.9 ± 28.8 | 25.8 ± 30.5* | 27.0 ± 32.2 | | IL-10 (pg/mL) | 1.7 ± 2.7 | 5.1 ± 5.1 | 1.8 ± 1.7 | 3.1 ± 3.1 | | IL-12 (pg/mL) | 25.9 ± 92.0 | 1.6 ± 0.8* | 2.6 ± 2.4 | 3.5 ± 3.1 | | IL-13 (pg/mL) | 2.1 ± 1.7 | 3.9 ± 4.8 | 2.1 ± 1.5 | 1.9 ± 1.6 | | GM-CSF (pg/mL) | 16.8 ± 27.1 | 49.3 ± 60.1 | 23.8 ± 35.9 | 2.4 ± 2.6 | | IFN-γ (pg/mL) | 15.1 ± 20.8 | 11.8 ± 23.8 | 12.1 ± 19.3 | 8.7 ± 8.7 | | TNF-α (pg/mL) | 10.9 ± 25.6 | 15.4 ± 38.6 | 10.9 ± 27.6 | 8.2 ± 12.2 | | G-CSF (pg/mL) | 8.8 ± 7.2 | 18.8 ± 10.5* | 9.1 ± 5.8 | 8.8 ± 3.7 | | MCP-1 (pg/mL) | 33.6 ± 14.2 | 99.3 ± 105.4* | 28.8 ± 16.9 | 41.9 ± 40.0 | | MIP-1β (pg/mL) | 86.7 ± 26.2 | 168.2 ± 167.3 | 91.7 ± 26.3 | 138.4 ± 212.5 |
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. Wilcoxon signed rank test compared with prechemotherapy. GM-CSF: granulocyte macrophage colony-stimulating factor. G-CSF: granulocyte-colony-stimulating factor. TNF: tumor necrosis factor. MCP-1: monocyte chemotactic protein-1. MIP-1β: macrophage inflammatory protein-1β.
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