Multiple Congenital Anomalies after Assisted Reproductive Technology in Japan (between 2004 and 2009)

Table 1

Distribution of classification of cases with congenital anomalies using the EUROCAT computer algorithm.

Number of diseases before algorithm application		Classification after algorithm		Final classification				EUROCAT registries
	𝑁		𝑁			𝑁	%	𝑁	%
		Isolated	912	Chromosomal cases		203	15.3%	2,653	15.0%
One	1,115	Chromosomal cases	167	Syndromes		45	3.4%	394	2.2%
		Syndromes	36	Isolated		980	74.0%	13,381	75.5%
				MCAs		96	7.3%	1,305	7.4%^a
		Isolated	68		1	24
		Neural tube defect isolated^b	5		2	56
		Isolated cardiac^b	53	Number of ICD subcategories	3	10
More than one	209	Isolated renal^b	2		4	5
		Isolated other^b	8		5	1
		Chromosomal cases	36
		Syndromes	9
		MCAs	96
Total	1,324		1,324			1,324		17,733

^aNumber and % for “true” congenital multiple anomalies.
^bThese categories are specifically prepared in the algorithm.
EUROAT: European surveillance of congenital anomalies, ICD: International Classification of Disease.
MCAs: multiple congenital anomalies.