Table of Contents
ISRN Urology
Volume 2013, Article ID 458353, 7 pages
http://dx.doi.org/10.1155/2013/458353
Review Article

Should Finasteride Be Routinely Given Preoperatively for TURP?

1Department of Urology, University Hospital of Wales, Cardiff CF14 4XW, UK
2Royal Bournemouth Hospital, Bournemouth, UK

Received 28 April 2013; Accepted 19 June 2013

Academic Editors: A. K. Singla and H. Tezval

Copyright © 2013 O. M. Aboumarzouk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim of the review was to compare the use of finasteride to placebo in patients undergoing TURP procedures. Material & Methods. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (1966–November 2011), EMBASE (1980–November 2011), CINAHL, Clinicaltrials.gov, Google Scholar, reference lists of articles, and abstracts from conference proceedings without language restriction for studies comparing finasteride to placebo patients needing TURPs. Results. Four randomised controlled trials were included comparing finasteride to a placebo. A meta-analysis was not conducted due to the disparity present in the results between the studies. Three of the studies found that finasteride could reduce either intra- or postoperative bleeding after TURP. One study found finasteride to significantly lower the microvessel density (MVD) and vascular endothelial growth factor (VEGF). None of the studies reported any long-term complications related to either the medication or the procedure. Conclusion. finasteride reduces bleeding either during or after TURP.