5 mg finasteride for 2 weeks prior to TURP or placebo
MVD: measured by counting stained blood vessels in 10 consecutive nonoverlapping high power fields (×200) beneath the prostatic urothelium on two slides
VEGF: (proportion of staining versus absent/faint staining)
5 mg finasteride for 2 weeks prior to TURP or placebo
Measured HB before and after TURP (recovery room) and the following day. Blood loss during surgery: measuring HB concentration in the irrigating fluid multiplied by the total volume of irrigating fluid used.
August 1998–May 1999 Seemed to include pateints with PSAs < 2
5 mg finasteride for 12 weeks prior to TURP or placebo
Blood loss was measured by Hb concentration in each collecting bucket which was measured in duplicate by a HemoCue Low HB System, consisting of a photometer and disposable microcuvettes. The mean of the two values was multiplied by the fluid volume to yield the Hb content in each bucket. The total blood loss was obtained as the sum of the Hb content in all buckets used divided by the preoperative blood Hb concentration.
MVD: counting the number of blood vessels below the suburothelial connective tissue with an average vessel density per unit grid obtained as the mean of 30 grids per patient.