Table of Contents
ISRN Spectroscopy
Volume 2013 (2013), Article ID 459820, 4 pages
http://dx.doi.org/10.1155/2013/459820
Research Article

Simultaneous Estimation of Pantoprazole Sodium and Levosulpiride in Capsule Dosage Form by Simultaneous Equation Spectrophotometric Method

Indukaka Ipcowala College of Pharmacy, Beyond GIDC, P.O. Box No. 53, Vitthal Udyognagar, Gujarat 388 121, India

Received 28 February 2013; Accepted 19 April 2013

Academic Editors: S. Rojas and Z. Wang

Copyright © 2013 Dimal A. Shah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple, accurate, and precise spectrophotometric method was developed for simultaneous estimation of pantoprazole sodium and levosulpiride in capsule dosage form. Simultaneous equation was developed at 290 and 232 nm. The method was found to be linear in the range of 4–12 μg/mL for pantoprazole sodium and 8–20 μg/mL for levosulpiride while accuracy of the method was confirmed by recovery studies of capsule dosage form and was found to be 100.23–100.99% and 100.51–100.94% for pantoprazole sodium and levosulpiride, respectively, in their capsule dosage form. The proposed method was validated and found to be accurate and precise. The method was successfully applied for the estimation of pantoprazole sodium and levosulpiride from their capsule dosage form.