Hematological and Genetic Predictors of Daytime Hemoglobin Saturation in Tanzanian Children with and without Sickle Cell Anemia
Table 1
Daytime pulse oximetry data, haematological and haemolytic indices and iron status in Tanzanian SCA and non-SCA children.
Variable
SCA children with daytime oximetry ()
Non-SCA children with daytime oximetry ()
Pulse oximetry
Median daytime SpO2 (%)
97 (IQ range 94–99)
99 (IQ range 98–100)***
Haematology
Mean hemoglobin* (g/dL)
7.4 (SD 1.17)
10.9 (SD 2.2)***
Mean red cell count × 10−9
2.89 (SD 0.66)
4.71 (SD 0.86)***
Mean cell hemoglobin concentration (g/dL)
31.9 (SD 1.52)
32.3 (SD 1.60)**
Mean cell hemoglobin (pg/cell)
26.1 (SD 3.31)
23.6 (SD 3.86)***
Mean cell volume* (fL)
79.5 (SD 15.28)
73.1 (SD 9.21)***
Median reticulocyte % ()
12.8 (IQ range 9.1–16.4)
2.4 (IQ range 0.8–6.7)***
Median hemoglobin F (Hb%) ()†
4.7 (IQ range 2.8–7.9)
0.6 (IQ range 0.2–1.0)***
Haemolytic markers
Median lactate dehydrogenase (IU) ()
762 (533–1121)
498 (367–671)***
Median unconjugated bilirubin (mol/L) ()
33.3 (IQ range 18.2–61.1)
7.2 (IQ range 3.5–12.5)***
Iron status
Median transferrin saturation (%) ()
20.9 (IQ range 15.4–27.7)
14.9 (IQ range 9.1–25.3)**
Median serum iron (mol/L) ()
11.5 (SD 5.7) (range 8.6–14.9)
10.0 (SD 8.5) (range 5.8–17.2)
Mean serum TIBC (mol/L) ()
55.3 (SD 10.9) (range 47.7–62.75)
70.5 (SD 22.3) (range 50.4–84.3)***
Iron deficiency transferrin saturation < 16%
126/458 (27.5%)
32/62 (51.6%)***
Within the SCA children, HbF% was not assessed at the same time point as the hematology and SpO2 data and was limited to children older than 5 years at the time of measurement of HbF% & SpO2. HbF% was available for some non-SCA children and was measured at the same time point as the SpO2. , , .
