Table 1: Daytime pulse oximetry data, haematological and haemolytic indices and iron status in Tanzanian SCA and non-SCA children.

Variable SCA children with daytime oximetry ( )Non-SCA children with daytime oximetry ( )

Pulse oximetry
 Median daytime SpO2 (%)97 (IQ range 94–99)99 (IQ range 98–100)***
Haematology
 Mean hemoglobin* (g/dL)7.4 (SD 1.17) 10.9 (SD 2.2)***
 Mean red cell count × 10−92.89 (SD 0.66) 4.71 (SD 0.86)***
 Mean cell hemoglobin concentration (g/dL)31.9 (SD 1.52) 32.3 (SD 1.60)**
 Mean cell hemoglobin (pg/cell)26.1 (SD 3.31)23.6 (SD 3.86)***
 Mean cell volume* (fL)79.5 (SD 15.28) 73.1 (SD 9.21)***
 Median reticulocyte % ( )12.8 (IQ range 9.1–16.4)2.4 (IQ range 0.8–6.7)***
 Median hemoglobin F (Hb%) ( )4.7 (IQ range 2.8–7.9)0.6 (IQ range 0.2–1.0)***
Haemolytic markers
 Median lactate dehydrogenase (IU) ( )762 (533–1121)498 (367–671)***
 Median unconjugated bilirubin ( mol/L) ( )33.3 (IQ range 18.2–61.1)7.2 (IQ range 3.5–12.5)***
Iron status
 Median transferrin saturation (%) ( )20.9 (IQ range 15.4–27.7)14.9 (IQ range 9.1–25.3)**
 Median serum iron ( mol/L) ( )11.5 (SD 5.7) (range 8.6–14.9)10.0 (SD 8.5) (range 5.8–17.2)
 Mean serum TIBC ( mol/L) ( )55.3 (SD 10.9) (range 47.7–62.75)70.5 (SD 22.3) (range 50.4–84.3)***
 Iron deficiency transferrin saturation < 16%126/458 (27.5%)32/62 (51.6%)***

Within the SCA children, HbF% was not assessed at the same time point as the hematology and SpO2 data and was limited to children older than 5 years at the time of measurement of HbF% & SpO2. HbF% was available for some non-SCA children and was measured at the same time point as the SpO2.
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