Hematological and Genetic Predictors of Daytime Hemoglobin Saturation in Tanzanian Children with and without Sickle Cell Anemia

Table 2

Predictors of daytime SpO₂ in SCA.

Explanatory variable	𝛽-coefficient	𝑃 value	Adj 𝑟^2
Hematological indices
Hemoglobin (g/dL)	0.35	0.007	0.014
RBC × 10^−9	1.10	<0.001	0.050
MCHC (g/dL)	−0.57	<0.001	0.073
MCH	−0.29	<0.001	0.090
MCV (fl)	−0.02	0.041	0.007
HbF% (𝑁=315)^†	0.12	<0.001	0.026
Iron status and nutritional status
Transferrin saturation %	−0.03	0.03	0.008
BMI Z-score (𝑁=451)	0.18	0.049	0.006
Hemolytic markers
Lactate dehydrogenase (IU) {natural log} (𝑁=427)	−0.72	0.011	0.013
Unconjugated bilirubin (𝜇mol/L) {natural log} (𝑁=415)	−0.34	0.029	0.009
𝛼-thalassemia genotype
3.7 heterozygote versus Wild Type	1.29	<0.001
3.7 homozygote versus Wild Type	2.04	<0.001	0.056*
G6PD genotype
Heterozygote females versus Wild Type	−0.52	0.276
Homozygote females and affected males versus Wild Type	−1.30	0.005	0.014*

𝑁=458 unless otherwise stated. ∗Adj 𝑟² for whole model. †Analysis of SpO₂ limited to those with HbF and SpO₂ measured when patients were 5 years or older.