Long-Term Outcome of Liver Transplantation in HIV-1-Positive Patients: 15-Year Follow-Up

Table 2

Characteristics of HIV-infected patients and LT.

No.

Age year

Gender

Transmission risk factor

Diagnosis

Pre-LT HAART

Pre-LT CD4^+/µL. ref. 490–1340

Pre-LT CD8^+/µl. ref. 190–800

Pre-LT HIV RNA copies/mL

Pre-LT HCV RNA (and HBV DNA*) IU/mL

LTx date

Liver and operation characteristics

0-liver biopsy

1

49

M

Transfusion

Hemophilia A, HIV with HCV

3TC, d4T, NFV

303

1186

<50

1.2×10^7

Aug '98

Single AA, CCS, CCA, VVB

Mild ischemia

No steatosis

2

58

M

Transfusion

Hemophilia A, HIV with HCV

ABC, ddI, LPV/r

410

1120

3000

1.3×10^6

Jun '00

Domino, Single AA, CCS, CCA,VVB

Moderate to severe ischemia

Severe steatosis

Mild portal fibrosis

3

60

M

Sexual

HIV (PHI) with PBC

None

NA

NA

<50

(Negative anti-HCV antibody)

Jun '00

Double AA, CCS, CCA, VVB

Moderate ischemia

Discrete steatosis

Mild portal fibrosis

4

44

M

Transfusion

Hemophilia A, HIV with HCV

3TC, ZDV, NFV

240

500

<50

2.9×10^5

Jan '01

Single AA, CCS. CCA, VVB

Mild ischemia

Mild steatosis

Mild to moderate portal fibrosis

5-1

53

M

Transfusion

Hemophilia A, HIV with HCV

3TC, d4T, ddI

80

NA

<50

NA

May '01

Triple AA, CCS. CCA, VVB

Severe ischemia

Mild steatosis

Mild focal portal fibrosis

5-2

53

M

Transfusion

Hemophilia A, HIV with HCV

3TC, d4T, ddI

90

360

<50

6.95×10^5

Nov '01 reLT

Single AA, CJS. CCA, VVB

Mild to moderate ischemia

Discrete steatosis

No portal fibrosis

6

43

F

i.v. drugs/sexual

HIV with HCV

3TC, ZDV, RAL

318

532

<20

2.39×10^5

Nov '09

Single AA, CCS, PGB

Moderate ischemia

No steatosis

Mild to moderate portal fibrosis

7

46

M

i.v. drugs/sexual

HIV with HCV

TDF, FTC, LPV/r

238

198

<20

6560

Sep '10

Single AA, CCS, PGB

Moderate ischemia

No steatosis

No portal fibrosis

8

43

M

i.v. drugs

HIV with HCV

FTC,TDF, LPV/r

190

110

<20

13900

Aug '11

Single AA, CCS, PGB

Mild ischemia, discrete steatosis

Mild portal fibrosis

9

37

M

i.v. drugs

HIV with HCV and HBV

3TC, ABC, EFV

230

570

<20

6.39×10^5

May '12

Single AA, CCS, PGB

Mild to moderate

ischemia

No steatosis

No portal fibrosis

0*

∗Only for patient 9. Abbreviations: PHI: primary HIV-1 infection; PBC: primary biliary cirrhosis; 3TC: lamivudine; d4T: stavudine; NFV: nelfinavir; ABC: abacavir; ddI: didanosine; LPV/r: lopinavir/ritonavir; ZDV: zidovudine; RAL: raltegravir; TDF: tenofovir; FTC: emtricitabine; EFV: efavirenz; NA: not applicable; AA: arterial anastomosis; CCS: choledocho-choledochostomy; CJS: choledocho-jejunostomy; CCA: cavo-caval anastomosis; VVB: veno-venous bypass; PGB: piggy-back technique.