HIV-1 Genetic Variability and Clinical Implications

Figure 1

Steps of HIV-1 life cycle targeted by antiretroviral drugs and relative impact of HIV-1 subtype on resistance development. Blue boxes represent the crucial steps of HIV-1 life cycle targeted by antiretrovirals. Red boxes report the drug classes available in clinics and the HIV-1 genetic characteristics related to subtype potentially involved in resistance development. EIs: Entry inhibitors; IN: integrase; INI: integrase inhibitors; NRTIs: nucleotide reverse transcriptase inhibitor; NNRTI: non-NRTIs; RT: reverse transcriptase; PR: protease.