Effect of Diazepam on Severity of Acute Pancreatitis: Possible Involvement of Peripheral Benzodiazepine Receptors

Table 1

Effect of diazepam administration on pathological scores of pancreas tissue in cerulein-induced acute pancreatitis in mice; Sham: normal mice treated with normal saline (5 mL/kg i.p. and 2 µL i.c.v), NegCtrl: negative control treated with normal saline (5 mL/kg i.p. and 2 µL i.c.v), Diazepam: treated mice (5, 10, 20 mg/kg i.p. and 10 µg i.c.v.), Data are shown as means ± SEM, 𝑛=6 (Mann-Whitney 𝑈 test), *𝑃<0.05: significant difference compared to negative control group.

Group	Route	Edema	Leukocyte infiltration
Sham	i.p.	0.0	0.0
NegCtrl	i.p.	2.6 ± 0.2	2.6 ± 0.2
Diazepam (20 mg/kg i.p.)	i.p.	2.1 ± 0.3	2.3 ± 0.3
Diazepam (10 mg/kg i.p.)	i.p.	2.0 ± 0.3	2.1 ± 0.3
Diazepam (5 mg/kg i.p.)	i.p.	1.3 ± 0.2*	1.5 ± 0.2*
Diazepam (10 µg/mouse ICV)	i.c.v	2.2 ± 0.3	2.1 ± 0.4
Diaz + flu (diazepam 20 mg/kg + flumazenil 1 mg/kg)	i.p.	2.3 ± 0.3	2.4 ± 0.6