Research Article
Determination of Ranitidine in Human Plasma by SPE and ESI-LC-MS/MS for Use in Bioequivalence Studies
Table 2
Stability of ranitidine and propranolol under different conditions (
).
| | Conditions | Concentration (ng/mL) | | Drug | Nominal | Determined mean |
| | Freezing and thawing cycles | Ranitidine | 5.06 | 5.46 1.39% | | 407.13 | 429.99 1.17% | | Room temperature for 8 h | Ranitidine | 4.97 | 5.05 2.63% | | 411.44 | 423.99 2.01% | | Propranolol | 214 | 195 7.06% | | Storage at −20°C for 40 days | Ranitidine | 4.8 | 5.28 3.23% | | 390.79 | 400.33 4.05% | | Standard solutions for 12 h | Ranitidine | 5.00 | 5.15 0.87% | | 404.66 | 429.78 1.89% | | Propanolol | 185.2 | 181.2 7.06 |
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