In Vivo and In Vitro Antidiabetic Activity of Terminalia paniculata Bark: An Evaluation of Possible Phytoconstituents and Mechanisms for Blood Glucose Control in Diabetes

Table 2

Effect of AETPB on haemoglobin, glycosylated haemoglobin, serum insulin, and total protein in type 2 diabetic rats.

Groups	Dose (mg/kg)	Hb (g/dL)	HbA1c (%)	Serum insulin (μIU/mL)	TP (g/dL)
Control	Vehicle	13.92±0.15	5.90±0.22	9.06±0.17	7.21±0.26
Diabetic control	Vehicle	7.31±0.27^a	12.03±0.37^a	4.95±0.15^a	4.95±0.19^a
AETPB	100	11.67±0.25^b	7.34±0.20^b	6.74±0.21^b	6.26±0.22^b
AETPB	200	10.83±0.34^b	8.52±0.18^b	7.11±0.23^b	5.80±0.20^c
Glibenclamide	5	13.17±0.31^b	6.89±0.16^b	8.17±0.22^b	6.85±0.14^b

All data are expressed as mean ± SEM (𝑛=6). Vehicle: 0.2% CMC (5 mL/kg).
aP < 0.001 diabetic control compared with control.
bP < 0.001 AETPB 100, 200 mg/kg and glibenclamide 5 mg/kg compared with diabetic control.
cP < 0.05 AETPB 200 mg/kg compared with diabetic control.