Impact of Amending the Acetylcysteine Marketing Authorisation on Treatment of Paracetamol Overdose

Table 2

Acetylcysteine administration according to pattern of paracetamol overdose, presented as proportions.

Overdose pattern	Sept. 2011–Aug. 2012	Sept. 2012–Apr. 2013
Single time-point ingestion, <15 hours
Above “200-line”	22/22 (100%)	12/12 (100%)
Between “200-line” and “100-line”	39/76 (51%)	44/45 (98%)^†††
Below “100-line”	31/208 (15%)	22/135 (16%)
Nomogram not applicable
Staggered ingestion (>1 hour)	54/100 (54%)	47/59 (80%)^†
Late presentation (>15 hours)	12/23 (52%)	9/13 (69%)
Time of ingestion uncertain	8/18 (44%)	7/13 (54%)
Level not checked	2/36 (6%)	1/25 (4%)
Total	168/483 (34.8%)	142/302 (47.0%)^††

^†𝑃=0.0498, ^††𝑃=0.0079, ^†††𝑃=0.0029 versus earlier time period by Chi-square proportional tests.