Study on the Dynamic Changes in Synaptic Vesicle-Associated Protein and Axonal Transport Protein Combined with LPS Neuroinflammation Model
Figure 1
Microglia were responsing to LPS application. (a) Microglia have been significantly activated by increased levels of Ox42 in the striatum, as well as in the SN during one to three days. At the same time, the expression of COX2 increased as time passed. After mice were treated with LPS, SN and striatum were separated. The expressions of Ox42 and COX2 level were detected by Western blot analysis. LPS can cause neuroinflammation after intranigral injection. (b) Quantitative analysis of Ox42 and COX2 expression in SN and striatum during one to three days. Mean ± SD. (, , versus saline group). (c) The expression of Ox42 was examined by immunohistochemistry. Coronal sections of SN; immunohistochemistry staining with Ox42 antibody to visualize microglia at 1 d and 2 d after unilateral application of LPS to the pial surface or application saline on the control side.
