Study on the Dynamic Changes in Synaptic Vesicle-Associated Protein and Axonal Transport Protein Combined with LPS Neuroinflammation Model

Figure 3

Progressive degeneration of the nigral dopaminergic neurons after intrastriatal LPS. (a) Representative TH immunochemistry staining of coronal midbrain sections demonstrates that the numbers of TH-positive neurons and fibers in the substantia nigra pars compacta are gradually reduced by intrastriatal LPS injection. Note that those TH-positive neurons in the medial substantia nigra pars compacta area are spared; scale bar: top 200 μm, bottom 100 μm. (b) Stereological cell counts of the TH-positive neurons in the substantia nigra pars compacta (𝑛=5-6/group, ^∗𝑃<0.05, ^∗∗𝑃<0.01 versus saline group).

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