Table of Contents
ISRN Neurology
Volume 2013, Article ID 501327, 7 pages
http://dx.doi.org/10.1155/2013/501327
Clinical Study

Cognitive Dysfunction and Dementia in Primary Sjögren’s Syndrome

1Neuropsychology Unit, Service of Neurology, University Hospital of Strasbourg, 1 avenue Molière, 67000 Strasbourg, France
2ICube Laboratory and Strasbourg Federation of Translational Medicine (FMTS), University of Strasbourg and CNRS, Strasbourg, France
3Memory Resource and Research Centre (CMRR) from Alsace, University Hospital of Strasbourg, 1 avenue Molière, 67000 Strasbourg, France
4Department of Rheumatology, University Hospital of Strasbourg, 1 avenue Molière, 67000 Strasbourg, France
5Department of Internal Medicine and Immunology, University Hospital of Strasbourg, 1 avenue Molière, 67000 Strasbourg, France
6Department of Neurology, Hospital of La Rochelle, La Rochelle, France
7Department of Dermatology, University Hospital of Strasbourg, Faculty of Medicine, University of Strasbourg, Strasbourg, France
8National Referral Center for Autoimmune Diseases, University Hospital of Strasbourg, 1 avenue Molière, 67000 Strasbourg, France

Received 29 May 2013; Accepted 20 July 2013

Academic Editors: S. Erdem, M. Leone, R. Ruff, and S. Weis

Copyright © 2013 Frederic Blanc et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Primary Sjögren’s syndrome (PSS) is a frequent systemic autoimmune disease. In this study, we aimed to explore the cognitive impairment and the correlations with brain MRI. Methods. Twenty-five patients (mean age 55 ± 11.8 years, 21 females) with PSS were prospectively selected and tested with a French translation of the Brief Repeatable Battery for Neuropsychological Examination. The results were compared with the scores for 25 matched patients with multiple sclerosis (MS) and 25 controls. Brain lesions were assessed by brain MRI using the Wahlund classification. Results. Fifteen of the 25 PSS patients (60%) presented with cognitive disorders versus 19/25 MS patients (76%). Five patients had dementia in the PSS group. Speed of information processing, attention, immediate and long-term memory, and executive functions were frequently impaired. The mean duration of cognitive complaints was 5.6 ± 6.1 years, and the mean duration of PSS was 15.8 ± 14.0 years. A trend towards a correlation was found between the severity of cognitive impairment and the degree of white matter lesions (WML) ( , rho = 0.43). Conclusion. Cognitive impairment—mild or dementia—exists in patients with PSS. Further MRI studies are needed to better understand the precise neural basis of cognitive impairment in PSS patients.