Identification of T- and B-Cell Subsets That Expand in the Central and Peripheral Lymphoid Organs during the Establishment of Nut Allergy in an Adjuvant-Free Mouse Model
Figure 1
((a) and (b)) Transdermal sensitization followed by oral allergen challenge mouse model of hazelnut allergy. Groups of BALB/c ( to 7 per group) were sensitized with hazelnut (HN) protein (0.5 mg/mouse) via transdermal exposure as described in the method. Sensitization to hazelnut was confirmed by analysis of hazelnut-specific IgE antibody elevation in the serum upon exposure (a). Clinical reactions were evaluated by oral allergen challenge for up to 1 hr. Systemic anaphylaxis quantified by hypothermia responses is shown in (b).
