Table of Contents
ISRN Organic Chemistry
Volume 2013 (2013), Article ID 515810, 9 pages
http://dx.doi.org/10.1155/2013/515810
Research Article

The Potential of Isotopomers as a Test for the Vibrational Theory of Olfactory Sense Recognition

Molecular Structure Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69009 Heidelberg, Germany

Received 22 March 2013; Accepted 13 May 2013

Academic Editors: J. Drabowicz, G. Sekar, H. Wang, and Z. Wimmer

Copyright © 2013 Karel D. Klika. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The continuing debate over the basis of odorant recognition with respect to the molecular shape (“lock and key”) theory versus the vibrational theory could potentially be resolved by the testing of 13C-labeled odorants. The application of 13C isotopomers is discussed herein by means of DFT-calculated IR vibrations and Gibbs’ free energies (Δ ) for acetophenone and octan-1-ol, two odorants for which the 2D (deuterium) isotopomers have previously been shown to be discernible from their respective 1H (normal) counterparts by Drosophila melanogaster.