Propofol Protects against Ischemia/Reperfusion Injury Associated with Reduced Apoptosis in Rat Liver
Table 1
Changes in studied parameters (serum levels of ALT, AST, TNF-α, and caspase-3), hepatic tissue expression of Bcl-xL and Bax genes, and histopathological changes of liver in different groups.
Sham
I/R
I/R propofol 10
I/R propofol 20
Serum levels
ALT (U/L)
28 ± 2.2
87 ± 6.8*
59 ± 5.4†
51 ± 5.2†
AST (U/L)
53 ± 4.9
134 ± 9.5*
81 ± 7.2†
76 ± 7.3†
TNF-α (pg/mL)
62.5 ± 4.1
189.2 ± 16.8*
112.4 ± 9.2†
88.5 ± 6.9†‡
Caspase-3 (U/mL)
491.8 ± 34.3
783.2 ± 51.6*
579.4 ± 47.2†
546.1 ± 43.1†
Bcl-xL and Bax gene expression in liver tissue
Bcl-xL/Bax ratio
3.4 ± 0.6
0.41 ± 0.2*
1.3 ± 0.4†
1.8 ± 0.3†
Histopathological changes of liver
Reactive changes
0.1 ± 0.03
4.2 ± 0.3*
2.5 ± 0.1†
2.1 ± 0.08†
Cellular necrosis
0.0 ± 0.0
0.9 ± 0.04*
0.4 ± 0.06†
0.3 ± 0.05†
Data are presented as mean ± SEM. *: significant change compared to sham-operated group. †: significant change compared to I/R group. ‡: significant change compared to low propofol dose.
