Midkine Mediates Intercellular Crosstalk between Drug-Resistant and Drug-Sensitive Neuroblastoma Cells In Vitro and In Vivo

Table 1

Correlation of midkine staining in human tissues with prognostic indicators.

	Nuclear score				Cytoplasmic score
	Prechemo	𝑃	Postchemo	𝑃	Prechemo	𝑃	Postchemo	𝑃
Stage		0.46		0.16		0.23		0.22
I	3.0±0.0		3.0±0.0		1.3±0.9		0
II	3.0±0.0		3.0±0.0		0.0±0.0		3.0±0.0
III	1.8±1.1		2.0±1.0		0.0±0.0		2.8±0.4
IV	2.1±1.2		1.0±1.0		1.0±1.1		2.0±1.4
N-MYC Status		0.86		0.41		0.48		0.26
Nonamplified	2.2±1.2		1.8±1.2		0.8±1.1		1.8±1.3
Amplified	2.3±0.9		1.0±0.0		1.2±1.2		3±0
Histology		0.49		0.34		0.77		0.51
Favorable	2.4±0.8		2.0±1.0		0.8±1.0		3.0±0.0
Unfavorable	1.9±1.4		1.3±1.1		1.0±1.2		2.3±1.3
Age		0.17		0.20		0.22		0.90
<1 year	1.9±1.4		1.3±1.2		1.2±1.2		2.1±1.4
>1 year	2.6±0.7		2.2±1.0		0.6±0.9		2.2±1.2
Survival status		0.64		0.79		0.33		1
Survivor	2.1±1.2		1.5±1.1		0.8±1.1		2.3±1.1
Nonsurvivor	2.4±1.2		1.3±1.1		1.4±1.2		2.3±1.3