Cystathionine β-Lyase-Like Protein with Pyridoxal Binding Domain Characterized in Leishmania major by Comparative Sequence Analysis and Homology Modelling

Table 2

Most frequent conserved interactions observed in PLP binding domain.

Conserved amino acid	Interaction	Frequency**
Gly71	OP2, OP3	Mild
Met72	OP1	Less
Tyr95	π-π stacking, arene-cation interaction, OP1, OP2	High
Asp159	N–H	High
Ser191	OP1, OP2, OP3	High
Lys194	–CHO, OP1, OP2, OP3	High

∗∗On the basis of the number of times the conserved residue was found in a docking pose out of 100 poses. Less: not more than 15 times; mild: not more than 30 times; high: not less than 50%, that is, out of 100 docking poses minimum, we get this interaction50 times.