Research Article
Influence of Mikania laevigata Extract over the Genotoxicity Induced by Alkylating Agents
Table 2
Detection of DNA damage by comet assay (DF and DI) in blood cells of mice exposed to water, Mikania laevigata extract (MLE), and/or cyclophosphamide (CP) or methyl methanesulfonate (MMS) and sampled at 24 h (with and without pretreatment with MLE) or 48 h (with and without posttreatment with MLE).
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DI: damage index; DF: damage frequency; : number of individuals obtained from sum of independent experiments. aGroup sampled 24 h after treatment with an alkylating agent. bGroup sampled 48 h after treatment with an alkylating agent. cData significant in relation to water, EML in 24 h, < 0.01 (ANOVA, Tukey). dData significant in relation to group CP, < 0.01 (ANOVA, Tukey). eData significant in relation to 24 h at, < 0.001 (t-test). fData significant in relation to 48 h at, < 0.001 (t-test). |