Dietary Supplementation of Calendula officinalis Counteracts the Oxidative Stress and Liver Damage Resulted from Aflatoxin

Table 2

Effect of ethanol extract of Calendula on serum biochemical parameters in rats fed aflatoxins-contaminated diet.

Parameter	Groups
	Control	AFs	CE1	CE2	CE1 + AFs	CE2 + AFs
AST (U/mL)	248.32 ± 3.14^a	330.34 ± 4.22^d	239.4 ± 8.96^b	240.60 ± 6.42^a	283.0 ± 4.2^c	257.64 ± 3.24^a
ALT (U/mL)	75.36 ± 1.37^a	132.51 ± 4.05^c	73.2 ± 2.02^a	74.12 ± 2.69^a	109.2 ± 1.77^b	77.52 ± 1.33^a
ALP (U/L)	106.75 ± 6.23^a	234.51 ± 5.32^b	93.67 ± 3.24^a	104.36 ± 3.33^a	156.71 ± 3.43^c	111.37 ± 2.61^d
TP (mg/dL)	9.99 ± 1.41^a	4.35 ± 0.31^b	9.23 ± 0.46^a	10.44 ± 1.61^a	8.95 ± 0.27^c	9.27 ± 0.23^c
Albumin (mg/dL)	3.44 ± 0.20^a	1.88 ± 0.12^b	3.11 ± 0.07^a	3.37 ± 0.12^a	3.07^c  ± 0.14	3.16 ± 0.22^a
Urea (mg/dL)	1.51 ± 0.14^a	3.44 ± 0.31^b	1.72 ± 0.13^a	1.61 ± 0.13^a	2.34 ± 0.12^a	1.84 ± 0.32^a
Creatinine (mg/dL)	0.77 ± 0.21^a	3.33 ± 0.14^b	0.75 ± 0.13^a	0.76 ± 0.14^a	2.03 ± 0.02^c	0.87 ± 0.13^d
AFP (ng/mL)	1.52 ± 0.78^a	4.64 ± 0.22^b	1.53 ± 0.17^a	1.44 ± 0.16^a	2.77 ± 0.31^c	1.59 ± 0.23^a

Within each row, means superscript with different letters are significantly different at 𝑃 ≤ 0.05.
AFs: aflatoxins.
CE1: low dose of calendula extract (500 mg/kg b.w).
CE2: high dose of calendula extract (1000 mg/kg b.w).