Simple and Sensitive Methods for the Determination of 2-(4′-Chloromethyl phenyl) Benzonitrile and 2-(4′-Bromomethyl phenyl) Benzonitrile Contents in Valsartan Drug Substance by Gas Chromatography

Table 1

Statistical data of linearity, LOD/LOQ for 2-CMPB and 2-BMPB.

Statistical parameters	2-CMPB	2-BMPB
Correlation coefficient	0.9993	0.9995
Intercept	−0.009	0.0170
Residual standard on deviation response	0.033	0.0101
Slope	1.065	0.4967
Concentration range (µg mL^−1)	0.32–2.40	0.95–2.38
Limit of detection (µg mL^−1)^a	0.1	0.31
Limit of quantification (µg mL^−1)^a	0.32	0.95
Precision for limit of detection (% RSD)	5.2	6.8
Precision for limit of quantification (% RSD)	3.2	5.2

^aPrecised LOD and LOQ values.