The Not4 RING E3 Ligase: A Relevant Player in Cotranslational Quality Control
Figure 3
Common features of mRNA surveillance upon NDM, NGD, and NSD. After endonucleolytic cleavage upstream of a stalled ribosome, 3′ to 5′ degradation by the exosome, 5′ to 3′ degradation by the Xrn1 exonuclease, and deadenylation by the Ccr4-Not complex will occur. In all cases the ribosome will be released and the translation product degraded by the proteasome (adapted from [71]).
