Different Neural Responses to a Moral Valence Decision Task in Unipolar and Bipolar Depression

Table 1

Gray matter areas showing a significant interaction of diagnosis and moral valence of the stimuli. Data are shown for the maximal activations in each Brodmann’s area (BA): lateralization (L/R), MRIh coordinates (𝑥,𝑦,𝑧) of voxels with higher 𝑍 values (signal peaks), and level of significance. Glass-brain images of these data are shown in Figure 1.

Comparison	Region	Side	BA	Signal peak	𝐹	𝑍	𝑃
Unipolar patients versus control subjects	Ventrolateral prefrontal cortex
	Middle Frontal Gyrus	Left	47	−30 40 −8	13.90	3.35	0.000
	Temporal cortex
	Superior temporal gyrus	Right	41	54 −28 12	7.81	2.47	0.007
	Insula	Right	13	48 −36 18	7.34	2.38	0.009
	Parietal cortex
	Superior parietal lobule	Right	7	32 −72 52	7.94	2.49	0.006
	Paracentral lobule	Right	5	20 −48 50	7.90	2.48	0.006
Bipolar patients versus control subjects	Dorsolateral prefrontal cortex
	Middle frontal gyrus	Left	10	−24 52 8	12.20	3.14	0.001
	Superior frontal gyrus	Right	10	24 50 30	9.50	2.75	0.003
	Medial prefrontal cortex
	Medial frontal gyrus	Right	9	4 38 30	12.04	3.11	0.001
	Medial frontal gyrus	Left	9	−2 42 32	9.32	2.72	0.003
	Ventrolateral prefrontal cortex
	Inferior frontal gyrus	Left	45	−50 36 4	9.17	2.70	0.004
	Frontal lobe
	Precentral gyrus	Left	6	−50 0 30	7.99	2.50	0.006
	Cingulate cortex
	Anterior	Right	32	6 20 32	11.11	2.99	0.001
	Posterior	Left	24	−2 −18 42	10.59	2.91	0.002
	Temporal cortex
	Middle temporal gyrus	Right	39	42 −76 28	13.78	3.34	0.000
	Superior temporal gyrus	Right	41	54 −30 10	10.08	2.84	0.002
	Superior temporal gyrus	Left	22	−58 −60 12	8.45	2.58	0.005
	Insula	Right	13	48 −36 18	11.65	3.06	0.001
	Parietal cortex
	Precuneus	Left	19	−32 −82 40	13.42	3.29	0.000
	Occipital cortex
	Cuneus	Right	18	4 −96 16	9.92	2.81	0.002
	Middle occipital gyrus	Left	19	−32 −88 16	8.76	2.63	0.004
	Lentiform nucleus
	Medial globus pallidus	Left		−10 0 2	8.56	2.60	0.005
	Lateral globus pallidus	Right		14 6 −2	10.64	2.92	0.002
	Subthalamic nucleus	Left		−12 –16 −4	9.05	2.68	0.004
Unipolar patients versus bipolar patients	Ventrolateral prefrontal cortex
	Inferior frontal gyrus	Left	47	−32 32 −6	11.43	3.03	0.001
	Parietal cortex
	Precuneus	Left	7	−18 −82 46	9.85	2.80	0.003
	Precuneus	Left	19	−12 −88 40	8.57	2.60	0.005