Table of Contents
ISRN Dermatology
Volume 2013, Article ID 586915, 5 pages
Clinical Study

Mucosal Melanoma in the Head and Neck Region: Different Clinical Features and Same Outcome to Cutaneous Melanoma

Institute of Oncology, University of Istanbul, Capa, 34390 Istanbul, Turkey

Received 3 April 2013; Accepted 24 April 2013

Academic Editors: S.-C. Chao, E. Pasmatzi, Y. Tuzun, and J. F. Val-Bernal

Copyright © 2013 Faruk Tas and Serkan Keskin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mucosal melanoma (MM) in the head and neck (H&N) is relatively rare and behaves in distinct pattern from cutaneous melanoma (CM). We performed this study to define clinical characteristics and outcomes of patients and emphasize MM differences from CM. Forty-one patients with MM located in H&N were assessed. 94 CM patients originated from H&N region were also used for comparison. Patients had oral cavity (51%) and sinonasal location (49%).The median age was 60 years and gender distribution was equal. Thirty-two (78%) patients had localized stage, four (10%) patients had regional lymph node metastasis, and five (12%) patients had distant metastasis. The 1- and 5-year overall survival rates were 81% and 58%, respectively. Outcomes were similar between sinonasal and oral cavity patients ( ). Advanced disease was the significant prognostic factor for outcome ( ). MM patients are older ( ) and more diagnosed as a localized disease patients at presentation than those with CM ( ). Overall survival rates were identical in patients with MM and CM ( ). In conclusion, despite different clinical features, outcome was identical in patients with MM and CM located in the H&N region.