Table of Contents
ISRN Organic Chemistry
Volume 2013, Article ID 587054, 7 pages
http://dx.doi.org/10.1155/2013/587054
Research Article

Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents

Faculty of Pharmacy, Organic Chemistry Department, Al-Azhar University, Cairo 11884, Egypt

Received 26 June 2013; Accepted 13 August 2013

Academic Editors: A. Hajra, R. Pohl, and F. L. Van Delft

Copyright © 2013 Mohamed Alswah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

2-([1,2,4]Triazolo[4,3-a]quinoxalin-4-ylthio)acetic acid hydrazide (10) was used as a precursor for the syntheses of novel quinoxaline derivatives with potential anticonvulsant properties. The newly synthesized compounds have been characterized by IR, 1H NMR, and mass spectral data followed by elemental analysis. The anticonvulsant evaluation was carried out for eleven of the synthesized compounds using metrazol induced convulsions model and phenobarbitone sodium as a standard. Among this set of tested compounds, two of them (14, and 15b) showed the best anticonvulsant activities.