International Scholarly Research Notices / 2013 / Article / Tab 1

Research Article

Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents

Table 1

Anticonvulsant activity of the tested compounds.

Drug/test compoundDose
mg/Kg
No. of
mice
No. of
mice
protected
Protection
%
ED50%
mg/kg
Mol. Wt.ED50%
mmol/kg
Relative potency to phenobarbitone
sodium

Phenobarbitone sodium6.25
12.5
25
6
6
6
1
3
6
16.66
50
100
12.52540.0491.00
8a20
40
80
6
6
6
0
3
5
0
50
66.66
403350.1190.41
9e20
40
80
6
6
6
1
3
5
16.66
50
83.33
403160.1260.38
1020
40
80
6
6
6
1
2
3
16.66
33.33
50
802740.2910.16
1220
40
80
6
6
6
1
3
5
16.66
50
83.33
403400.1170.41
1420
40
80
6
6
6
2
4
5
33.33
66.66
83.33
303990.0750.65
15a20
40
80
6
6
6
2
4
5
33.33
66.66
83.33
303610.0830.58
15b20
40
80
6
6
6
2
4
5
33.33
66.66
84.33
304090.0730.66
1620
40
80
6
6
6
2
4
5
33.33
66.66
83.33
303160.0940.51
17a20
40
80
6
6
6
0
3
5
0
50
66.66
403620.1100.44
17d20
40
80
6
6
6
1
3
5
16.66
50
66.66
403780.1050.46
17e20
40
80
6
6
6
0
1
3
0
16.66
50
803960.2020.24

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