Research Article
Synthesis and Biological Evaluation of Some [1,2,4]Triazolo[4,3-a]quinoxaline Derivatives as Novel Anticonvulsant Agents
Table 1
Anticonvulsant activity of the tested compounds.
| | Drug/test compound | Dose
mg/Kg
| No. of
mice | No. of
mice
protected | Protection
% | ED50%
mg/kg | Mol. Wt. | ED50%
mmol/kg | Relative potency to phenobarbitone
sodium |
| | Phenobarbitone sodium | 6.25
12.5
25 | 6
6
6 | 1
3
6 | 16.66
50
100 | 12.5 | 254 | 0.049 | 1.00 | |
8a | 20
40
80 | 6
6
6 | 0
3
5 | 0
50
66.66 | 40 | 335 | 0.119 | 0.41 | | 9e | 20
40
80 | 6
6
6 | 1
3
5 | 16.66
50
83.33 | 40 | 316 | 0.126 | 0.38 | | 10 | 20
40
80 | 6
6
6 | 1
2
3 | 16.66
33.33
50 | 80 | 274 | 0.291 | 0.16 | | 12 | 20
40
80 | 6
6
6 | 1
3
5 | 16.66
50
83.33 | 40 | 340 | 0.117 | 0.41 | | 14 | 20
40
80 | 6
6
6 | 2
4
5 | 33.33
66.66
83.33 | 30 | 399 | 0.075 | 0.65 | | 15a | 20
40
80 | 6
6
6 | 2
4
5 | 33.33
66.66
83.33 | 30 | 361 | 0.083 | 0.58 | | 15b | 20
40
80 | 6
6
6 | 2
4
5 | 33.33
66.66
84.33 | 30 | 409 | 0.073 | 0.66 | | 16 | 20
40
80 | 6
6
6 | 2
4
5 | 33.33
66.66
83.33 | 30 | 316 | 0.094 | 0.51 | | 17a | 20
40
80 | 6
6
6 | 0
3
5 | 0
50
66.66 | 40 | 362 | 0.110 | 0.44 | | 17d | 20
40
80 | 6
6
6 | 1
3
5 | 16.66
50
66.66 | 40 | 378 | 0.105 | 0.46 | | 17e | 20
40
80 | 6
6
6 | 0
1
3 | 0
16.66
50 | 80 | 396 | 0.202 | 0.24 |
|
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