Table of Contents
ISRN Nanotechnology
Volume 2013, Article ID 591751, 6 pages
Research Article

Development and Evaluation of Insulin Incorporated Nanoparticles for Oral Administration

1Institute of Pharmacy and Technology, Salipur, Cuttack, Odisha 754 202, India
2University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Odisha, India

Received 15 May 2013; Accepted 27 June 2013

Academic Editors: K. H. Park, Z. Shi, and H. Tang

Copyright © 2013 Amiya kumar Prusty and Susanta Kumar Sahu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The current study was designed to prepare and characterize insulin incorporated nanoparticles by complex coacervation process followed by antidiabetic study of orally administered insulin incorporated nanoparticles in diabetic rats. The nanoparticles were characterized for particle size, loading and entrapment efficiency as well as in vitro release of incorporated insulin. The prepared nanoparticles were found to have an average particle size of 551.67 nm . The highest entrapment efficiency and loading capacity values were found to be of and , respectively. Oral administration of 10 IU/Kg of insulin loaded nanoparticles to diabetic rats showed a maximum blood glucose change of at 5-hours time period. The results obtained indicate the potential of prepared nanoparticulate system as a carrier for oral delivery of insulin.