MicroRNAs in Cardiovascular Regenerative Medicine: Directing Tissue Repair and Cellular Differentiation
Figure 3
(a) A full length coding mRNA, finally translated into protein, has an untranslated portion ending its 3′coding sequence (CDS), called the untranslated region (3′-UTR). Several different miRNAs (different colors) can bind to a single mRNA (CDS-1), whereas (b) a single miRNA can also bind to different target mRNA sequences (CDS2-4). (c) Mature miRNA binds to in an imperfect manner, meaning that not the full nucleotide length binds to the corresponding sequence but only parts. The nucleotides 2–7 of the miRNA are called the seed region.
