Figure 2: uPA/uPAR signal transduction. The binding of uPA to uPAR can trigger the activation of intracellular signal transduction either by interacting with α5β1 integrin which allows the transactivation of EGFR by a mechanism mediated by FAK and Scr to in turn activate RAS-ERK1 MAPK, or by interacting with α6β1 integrin to also activate RAS-ERK signal.