Competitive HIF Prolyl Hydroxylase Inhibitors Show Protection against Oxidative Stress by a Mechanism Partially Dependent on Glycolysis

<table>Neuroprotective effect of HPH inhibitors. (a) ATP-levels in SH-SY5Y cells grown overnight in starvation media, pretreated for 3 hours with 25 <i>μ</i>M of FG41 (a), DFO (b), CpdA (c), or JNJ (d) followed by 6-OHDA treatment for 3 hours. (e) Mitochondrial membrane potential in SH-SY5Y cells treated with Cpd A (10 or 25 <i>μ</i>M) for 3 hours followed by 3 hours treatment with 50 <i>μ</i>M 6-OHDA. Asterisks indicate levels significantly increased (<i>t</i>-test) as compared to control. </table>

International Scholarly Research Notices

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Figure 4

Figure 4: Competitive HIF Prolyl Hydroxylase Inhibitors Show Protection against Oxidative Stress by a Mechanism Partially Dependent on Glycolysis 