Competitive HIF Prolyl Hydroxylase Inhibitors Show Protection against Oxidative Stress by a Mechanism Partially Dependent on Glycolysis
Figure 6
FG41 induces stabilization and nuclear translocation of HIF-1α and dopamine release in PC12 cells. (a) Immunocytochemical detection of HIF-1α in PC12 cells after 3 hours treatment with FG41 (25 and 50 μM). (b) Cellomics ArrayScan quantification of the nuclear to cytoplasmatic ratio of HIF-1α after 6 or 24 hours of treatment with FG41 or Cpd (both used at 25 μM). (d) DA release from PC12-cells induced by 6 or 24 hours of treatment with FG41 or CpdA (25 μM).
