Research Article
Design and Characterization of Double Layered Mucoadhesive System Containing Bisphosphonate Derivative
Table 1
Compositions of buccal films.
| | Batch code | Risedronate sodium (g) | Chitosan (%w/v) | HPMC-4KM (%w/v) | Ethyl cellulose (g) | Propylene glycol (%w/w) | Acetic acid 1% V/V (mL) | Purified water (mL) |
| | A1 | 0.28 | 1 | 1 | 1 | 50 | 25 | 25 | | A2 | 0.28 | 1 | 0.5 | 1 | 25 | 30 | 20 | | A3 | 0.28 | 0.5 | 1 | 1 | 50 | 20 | 30 | | A4 | 0.28 | 0.75 | 0.88 | 1 | 37.5 | 20 | 30 | | A5 | 0.28 | 0.5 | 0.5 | 1 | 25 | 25 | 25 | | A6 | 0.28 | 0.75 | 0.75 | 1 | 25 | 25 | 25 | | A7 | 0.28 | 0.5 | 0.75 | 1 | 37.5 | 20 | 30 | | A8 | 0.28 | 1 | 0.5 | 1 | 50 | 30 | 20 | | A9 | 0.28 | 0.5 | 0.5 | 1 | 50 | 25 | 25 | | A10 | 0.28 | 0.5 | 01 | 1 | 25 | 20 | 30 | | A11 | 0.28 | 0.75 | 0.5 | 1 | 37.5 | 30 | 20 | | A12 | 0.28 | 1 | 1 | 1 | 25 | 25 | 25 | | A13 | 0.28 | 0.75 | 1 | 1 | 50 | 20 | 30 | | A14 | 0.28 | 1 | 0.75 | 1 | 37.5 | 30 | 20 |
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