Design and Characterization of Double Layered Mucoadhesive System Containing Bisphosphonate Derivative

Table 2

Evaluation parameters of mucoadhesive films.

Batch code	Thickness (mm) mean ± S.D	Mass uniformity (g) mean ± S.D	% drug content mean ±S.D	Surface pH mean ± S.D	Folding endurance mean ± S.D	%moisture absorption mean ± S.D	Vapour transmission mean ± S.D
A1	0.23±0.017	0.108±0.004	92.81±0.378	7.03±0.249	>300	9.424±0.227	0.0033±0.0003
A2	0.26±0.017	0.092±0.008	99.8±0.390	5.78±0.050	>300	9.976±0.125	0.0033±0.0002
A3	0.24±0.020	0.084±0.014	93.36±2.915	6.09±0.146	>300	10.620±0.228	0.0018±0.0004
A4	0.22±0.012	0.093±0.008	91.58±0.671	6.72±0.048	>300	18.050±0.096	0.0033±0.0003
A5	0.23±0.012	0.086±0.006	93.73±6.091	6.87±0.346	>300	6.870±0.450	0.0028±0.0001
A6	0.25±0.015	0.094±0.009	91.49±1.904	6.35±0.483	>300	8.330±0.321	0.0065±0.0028
A7	0.23±0.012	0.092±0.003	97.02±5.693	7.19±0.698	>300	6.370±0.120	0.0057±0.0002
A8	0.26±0.020	0.102±0.004	90.91±0.172	5.93±0.366	>300	9.860±0.225	0.0026±0.0001
A9	0.22±0.021	0.107±0.013	94.65±5.369	6.05±0.422	>300	7.370±0.218	0.0022±0.0031
A10	0.27±0.035	0.099±0.011	94.58±5.468	6.70±0.233	>300	7.630±0.198	0.0046±0.0003
A11	0.25±0.010	0.091±0.009	93.45±2.060	5.88±0.301	>300	8.710±0.278	0.0053±0.0021
A12	0.28±0.015	0.108±0.008	105.53±2.155	7.01±0.089	>300	10.920±0.283	0.0039±0.0038
A13	0.31±0.006	0.109±0.008	91.89±0.828	6.93±0.210	>300	10.370±0.089	0.0106±0.0002
A14	0.24±0.061	0.093±0.011	100.91±1.884	5.36±0.530	>300	11.480±0.158	0.0016±0.0002