Table of Contents
ISRN Pathology
Volume 2013, Article ID 604954, 6 pages
Clinical Study

Selenium Status in Patients Receiving Short-Term Parenteral Nutrition: Frequency of Deficiency and Response to a Standard Supplementation Regimen

1Department of Chemical Pathology, Royal Gwent Hospital, Cardiff Road, Newport, Gwent NP20 2UB, UK
2Department of Surgery, Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, Guildford, Surrey GU2 7XX, UK
3Department of Clinical Biochemistry, Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, Guildford, Surrey GU2 7XX, UK
4Trace Elements Supraregional Assay Service (SAS), Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK

Received 5 July 2013; Accepted 27 August 2013

Academic Editors: A. M. Lavezzi and P. J. Twomey

Copyright © 2013 Julia Walsh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. This study aimed to determine the prevalence and correlates of Se deficiency in patients referred for parenteral nutrition (PN) and to assess the response to a standard supplementation regimen. Methods. Adult patients (53) were recruited prior to commencing a PN regimen delivering 32 µg (0.4 µmol) Se per 24–36 h. Serum Se concentrations were measured before and daily during PN. Results. At baseline 49 (92%) patients had serum Se concentrations below the reference range (0.9–1.65 μmol/L). Se concentrations climbed during PN from (mean ± SD) to μmol/L ( ), but in 48 (91%) patients the concentrations remained low at post-PN. Taking a Se concentration below 0.6 μmol/L as indicative of depletion in the presence of an acute phase response (APR), 37 (70%) patients had Se depletion at baseline and in 27 (51%), levels remained low at post-PN. Baseline serum Se predicted the length of hospital stay ( , ). Increased “malnutrition universal screening tool” score predicted low Se ( , ). Conclusions. Patients referred for PN have a high prevalence of Se deficiency, even when the APR is taken into account. Se supplementation of 32 µg Se per 24–36 h is insufficient for most patients. Baseline serum Se may have prognostic value.