Table of Contents
ISRN Pharmacology
Volume 2013 (2013), Article ID 605640, 9 pages
http://dx.doi.org/10.1155/2013/605640
Research Article

On the Performance of Trimetazidine and Vitamin E as Pharmacoprotection Agents in Cyclosporin A-Induced Toxicity

1Clinical Biochemistry III, Instituto de Bioquímica Clínica, Facultad de Bioquímica Química y Farmacia, Universidad Nacional de Tucumán, Balcarce 747, Tucumán, 4000 San Miguel de Tucumán, Argentina
2Instituto de Bioquímica Clínica, Facultad de Bioquímica Química y Farmacia, Universidad Nacional de Tucumán, Balcarce 747, Tucumán, 4000 San Miguel de Tucumán, Argentina

Received 26 December 2012; Accepted 17 January 2013

Academic Editors: G. M. Campo, G. Edwards, and B.-N. Wu

Copyright © 2013 De la Cruz Rodríguez Lilia Cristina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Matsuda and S. Koyasu, “Mechanisms of action of cyclosporine,” Immunopharmacology, vol. 47, no. 2-3, pp. 119–125, 2000. View at Publisher · View at Google Scholar · View at Scopus
  2. E. Toscano, J. Cotta, M. Robles, M. I. Lucena, and R. J. Andrade, “Toxicidad hepática inducida por los nuevos fármacos inmunosupresores,” Gastroenterology and Hepatology, vol. 33, no. 1, pp. 54–65, 2010. View at Google Scholar
  3. G. Inselmann, H. U. Lawerenz, U. Nellessen, and H. T. Heidemann, “Enhancement of cyclosporin A induced hepato- and nephrotoxicity by glutathione depletion,” European Journal of Clinical Investigation, vol. 24, no. 5, pp. 355–359, 1994. View at Google Scholar · View at Scopus
  4. F. Serino, J. Grevel, K. L. Napoli, B. D. Kahan, and H. W. Strobel, “Oxygen radical formation by the cytochrome P450 system as a cellular mechanism for cyclosporine toxicity,” Transplantation Proceedings, vol. 26, no. 5, pp. 2916–2917, 1994. View at Google Scholar · View at Scopus
  5. I. Durak, M. Kacmaz, B. Cimen, S. Buyukkocak, S. Elagun, and S. Zturk, “The effect of cyclosporine on antioxidante enzyme activities and malondialdehide levels in rabbit hepatic tissues,” Transplant Immunology, vol. 10, pp. 255–258, 2002. View at Google Scholar
  6. D. Andrés, N. Sanz, A. Zaragoza, A. M. Alvarez, and M. Cascales, “Changes in antioxidant defence systems induced by cyclosporine A in cultures of hepatocytes from 2- and 12-month-old rats,” Biochemical Pharmacology, vol. 59, no. 9, pp. 1091–1100, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. C. R. Araujo, S. E. Posleman, and L. C. De la Cruz Rodríguez, “Changes in the antioxidante defence system induced by Cyclosporin A,” Acta Bioquímica Clínica Latinoamericana, vol. 41, no. 1, pp. 35–45, 2007. View at Google Scholar
  8. L. C. De la Cruz Rodríguez de Dantur, E. E. Del Sancio, S. E. Posleman, and cols, “Nefrotoxicidad por ciclosporina A evaluada mediante la gama glutamil transpeptidasa urinaria,” Nefrología Latinoamericana, vol. 3, no. 4, pp. 300–305, 1996. View at Google Scholar
  9. L. C. De la Cruz Rodríguez, S. E. Posleman, C. R. Araujo, and R. Rey Mdel, “Hepatotoxic effect of cyclosporine A in the mitochondrial respiratory Chain,” Journal of Applied Toxicology, vol. 26, pp. 310–317, 2007. View at Google Scholar
  10. R. Rezzani, “Exploring cyclosporine A-side effects and the protective role-played by antioxidants: the morphological and immunohistochemical studies,” Histology and Histopathology, vol. 21, no. 1–3, pp. 301–316, 2006. View at Google Scholar · View at Scopus
  11. L. A. Lexis, R. G. Fassett, and J. S. Coombes, “α-tocopherol and α-lipoic acid enhance the erythrocyte antioxidant defence in cyclosporine A-treated rats,” Basic and Clinical Pharmacology and Toxicology, vol. 98, no. 1, pp. 68–73, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. G. De Arriba, J. P. Homedo, S. R. Rubio et al., “Vitamin E protects against the mitochondrial damage caused by cyclosporin A in LLC-PK1 cells,” Toxicology and Applied Pharmacology, vol. 239, no. 3, pp. 241–250, 2009. View at Google Scholar
  13. T. Parra Cid, J. R. Conejo García, F. Carballo Álvarez, and G. De Arriba, “Antioxidant nutrients protect against cyclosporine A nephrotoxicity,” Toxicology, vol. 189, no. 1-2, pp. 99–111, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. J. K. Jenkins, H. Huang, K. Ndebele, and A. K. Salahudeen, “Vitamin E inhibits renal mRNA expression of COX II, HO I, TGFβ, and osteopontin in the rat model of cyclosporine nephrotoxicity,” Transplantation, vol. 71, no. 2, pp. 331–334, 2001. View at Google Scholar · View at Scopus
  15. Z. Mostafavi-pour, F. Zal, A. Monabati, and M. Vessal, “Protective effects of a combination of quercetin and vitamin E against cyclosporine A-induced oxidative stress and hepatotoxicity in rats,” Hepatology Research, vol. 38, no. 4, pp. 385–392, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. P. F. Kantor, A. Lucien, R. Kozak, and G. D. Lopaschuk, “The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long- chain 3-ketoacyl coenzyme A thiolase,” Circulation Research, vol. 86, no. 5, pp. 580–588, 2000. View at Google Scholar · View at Scopus
  17. M. Marzilli, “Cardioprotective effects of trimetazidine: a review,” Current Medical Research and Opinion, vol. 19, no. 7, pp. 661–672, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Monteiro, A. I. Duarte, L. M. Gonçalves, A. Moreno, and L. A. Providência, “Protective effect of trimetazidine on myocardial mitochondrial function in an ex-vivo model of global myocardial ischemia,” European Journal of Pharmacology, vol. 503, no. 1–3, pp. 123–128, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Grymberg, “Effectors of fatty acid oxidation reduction: promisgin new anti-ischaemic agents,” Current Pharmaceutical Design, vol. 11, pp. 489–509, 2005. View at Google Scholar
  20. H. Kaur, S. S. V. Padi, and K. Chopra, “Attenuation of renal ischemia-reperfusion injury by trimetazidine: evidence of an in vivo antioxidant effect,” Methods and Findings in Experimental and Clinical Pharmacology, vol. 25, no. 10, pp. 803–809, 2003. View at Publisher · View at Google Scholar · View at Scopus
  21. L. C. De la Cruz Rodríguez, C. R. Araujo, S. E. Posleman, and R. Rey Mdel, “Attenuation in gentamicina-induced neprhotoxicity: trimetazidine versus N-acetyl cysteine,” Journal of Applied Toxicology, vol. 30, pp. 343–353, 2010. View at Google Scholar
  22. J. K. Fawcet and J. E. Scott, “A rapid and precise method for the determination of urea,” Journal of Clinical Pathology, vol. 13, no. 2, pp. 156–157, 1960. View at Google Scholar
  23. H. G. Biggs and J. M. Cooper, “An evaluation of tour methods of measuring urinary creatinine,” Clinical Chemistry, vol. 7, no. 6, pp. 655–673, 1961. View at Google Scholar
  24. H. U. Bergmeyer, G. N. Bowers, M. Horder, and D. W. Moss, “Provisional recommendations on IFCC methods for the measurement of catalytic concentrations of enzymes. Part II. IFCC method for aspartate aminotransferase,” Clinical Chemistry, vol. 23, no. 5, pp. 887–899, 1977. View at Google Scholar · View at Scopus
  25. Deutsche Gesellschaft für Klinische Chemie, “Z. Clin Chem and Clin biochem,” 12, 391, 1974.
  26. R. Martoja, M. Martoja-Pierson, and L. C. Grumbles, Técnicas De Histología Animal, Toray-Masson; S.A. Barcellona, 1970.
  27. L. Spannhof, Histoquímica Teórica Y Práctica, Acribia, Zaragoza, Spain, 1996.
  28. J. Pérez De Hornedo, G. De Arriba, M. Calvino, S. Benito, and T. Parra Cid, “Cyclosporin A causes oxidative stress and mitochondrial dysfunction in renal tubular cells,” Nefrologia, vol. 27, no. 5, pp. 565–573, 2007. View at Google Scholar · View at Scopus
  29. G. De arriba, J. P. De Hornedo, S. R. Rubio et al., “Vitamin E protects against the mitochondrial damge caused by cyclosporin A in LLC-PK1 cells,” Toxicology and Applied Pharmacology, vol. 239, no. 3, pp. 241–250, 2009. View at Google Scholar
  30. J. Palomero, A. I. Galan, M. E. Munoz, M. J. Stump, J. González-Gallego, and R. Jimenez, “Effects of aging and cyclosporin treatment on the hepatobiliary efflux of glutathione,” Life Sciences, vol. 73, pp. 3387–3397, 2003. View at Google Scholar
  31. Z. Mostafavi-Pour, F. Zal, M. Ahmad, and M. Vessal, “Protective effects of a combination of quercetin and vitamin E against cyclosporine A-induced hepatotoxicity in oxidative stress and rats,” Hepatology Research, vol. 38, no. 4, pp. 385–392, 2008. View at Google Scholar