Table of Contents
ISRN Gastroenterology
Volume 2013, Article ID 605931, 4 pages
Research Article

Effect of Propofol on Acid Reflux Measured with the Bravo pH Monitoring System

1Division of Pediatric Gastroenterology, Stony Brook Long Island Children's Hospital, Health Science Center T11-080, Stony Brook, NY 11794, USA
2Department of Obstetrics and Gynecology and Women's Health, Belfer Educational Center, 1300 Morris Park Avenue, Room 501, Bronx, NY 10461, USA
3Division of Gastroenterology, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
4Department of Pediatric Emergency Medicine, Alpert School of Medicine of Brown University, 2nd Floor, 55 Claverick Street, Providence, RI 02903, USA

Received 31 January 2013; Accepted 17 March 2013

Academic Editors: A. Amedei, C.-T. Shun, A. A. Te Velde, and A. Weimann

Copyright © 2013 Anupama Chawla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background/Aim. The aim of this study was to determine the effect of propofol on acid reflux as measured with the Bravo pH monitoring system. Methods. 48-hour pH tracings of 88 children were retrospectively evaluated after placement of the Bravo capsule under propofol. Comparisons between day 1 and day 2, as well as 6-hour corresponding segments from day 1 and day 2, were made. Results. The number of reflux episodes was significantly increased during the first six-hour period on day one as compared to day 2 . The fraction of time the pH was <4 was also increased during this period, though it did not reach statistical significance. When comparing full 24-hour periods, there was no difference noted in either the number of reflux episodes or the fraction of time pH < 4 between day one and day two. Conclusion. Our data suggest an increase in gastroesophageal reflux during the postanesthesia period. This could be a direct effect of propofol, or related to other factors. Regardless of the cause, monitoring of pH for the first 6 hours following propofol administration may not be reliable when assessing these patients. Monitoring pH over a prolonged 48-hour time period can overcome this obstacle.