Melanoma M (Zero): Diagnosis and Therapy

Table 2

Melanoma clinical and histologic subtypes.

	%	Sun exposure	Localization	Clinical aspects	Colors	Histology
Superficial spreading melanoma	70	Intermittent	Back—Man; Legs—Woman	Flat; Papule; Nodule	Tan,; Brown, Gray, Black,; Violaceous, Pink	Radial growth; phase characterized by the proliferation within the epidermis of single atypical melanocytes in a pagetoid pattern
Nodular melanoma	5	Intermittent	Trunk; Limb	Nodule; Ulcerated polyp Elevated plaque	Brown; Black; Achromic	Radial growth; phase absent
Lentigo maligna melanoma	4–15	Long term	Head; Neck	Flat; Papula	Brown; Black	Radial growth; phase composed of a lentiginous proliferation atypical melanocytes at the dermo-epidermal junction
Acral lentiginoso melanoma	5	N/A	Glabrous skin; (palmoplantar, subungueal)	Flat; Nodule; Plaque	Irregular,; poorly circumscribed pigmentation	Radial growth; phase characterized by lentiginous proliferation of atypical melanocytes, marked acanthosis and elongation of the rete ridges of the epidermis
Desmoplastic melanoma	2	Long term	Head; Neck	Papule; Nodule	Erythemato; us Flash colored Achromic	Vertical growth; phase composed of atypical spindle cells embedded in a fibrous stroma
Melanoma arising from blu nevus	Rare	N/A	Head	Recent; history of enlargement or change in pre-existing nevus	Blu-Black	Malignant; dermal, deep seated component juxtaposed to a benign blue nevus
Melanoma arising in a giant	Rare	N/A	Trunk	Nodule; growing in	Dark,; brown	Dermal sharply; delineated nodule
Congenital nevus				A nevus	Black	Composed of atypical ephitelioid, spindle or small cells, arising in a preexisting giant congenital nevus
Melanoma of childhood	0,4	N/A	Trunk	SSM or NM	SSM: Tan,; Brown, Gray, Black,; Violaceous, Pink	Conventional epithelioid melanoma or small cells or melanoma simulating Spitz nevus
Nevoid melanoma	1-2	N/A	Leg, trunk	Small; papule	Tan to dark,; brown	Nevus-like; silhouette, limited intraepidermal component, loss/lack of maturation, cytological atypia, mitoses in the dermal component