Melanoma M (Zero): Diagnosis and Therapy

Table 4

Distribution of TNM staging according to pathologic and clinical features.

(a)

	Stage I		Stage II
T
	Not ulcerated	Ulcerated	Not ulcerated	ulcerated
0
1	A	B
2	A			B
3			A	B
4			A	C

(b)

Stage III
T
Not ulcerated	Ulcerated
Metastasis 1 lymph node	Metastasis 1 lymph node
Micro A	Micro B
Macro B	Macro —
Metastasis 2 or 3 lymph node or intralymphatic	Metastasis 2 or 3 lymph node or intralymphatic
Micro  A	Micro  B
Macro  B	Macro  —
Intransit C	Intransit C
Metastasis 4/+ lymph node, matted metastatic node, in transit MT with MT in regional LN	Metastasis 4/+ lymph node, matted metastatic node, in transit MT with MT in regional LN
Micro —	Micro C
Macro —	Macro C

(c)

Stage IV
LDH	Normal	Elevated
M1
Skin, subcutaneous, node	A	C
Lung	B	C
Any other	C	C

T1 ≤ 1 mm; T2 = 1,01–2,00 mm; T3 = 2,01–4,00 mm; T4 > 4,00 mm.
A-B-C: indicator of substaging; LDH: lactate dehydrogenase; M: metastases.