Table of Contents
ISRN Medicinal Chemistry
Volume 2013 (2013), Article ID 619535, 11 pages
http://dx.doi.org/10.1155/2013/619535
Research Article

Synthesis and Evaluation of Substituted 4,4a-Dihydro-3H,10H-pyrano[4,3-b][1]benzopyran-10-one as Antimicrobial Agent

1Bio-Organic and Photochemistry Laboratory, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab 143 005, India
2ISF College of Pharmacy, Moga, Punjab 143008, India
3Department of Microbiology, Guru Nanak Dev University, Amritsar, Punjab 143 005, India
4Post-Graduate Department of Physics, University of Jammu, Jammu-Tawi 180 006, India

Received 7 June 2013; Accepted 21 July 2013

Academic Editors: A. Contini, P. L. Kotian, and P. M. Sivakumar

Copyright © 2013 Amanpreet Kaur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of pyrano[4,3-b][1]benzopyranones (7a–t) were synthesized through hetero-Diels-Alder reaction of substituted 3-formylchromones (5) with enol ethers (6), characterized by IR, 1H NMR, 13C NMR, and mass spectral techniques. All the compounds were evaluated for antimicrobial activity against various bacterial and fungal strains, found to possess significant inhibitory potential, particularly, compounds bearing electron withdrawing group -fluoro such as 7i and 7h. Compounds were also tested and displayed a significant inhibitory potential against methicillin-resistant Staphylococcus aureus (MRSA).