Table of Contents
ISRN Organic Chemistry
Volume 2013, Article ID 620718, 8 pages
Research Article

Synthesis and Antioxidant Activity of 2-Amino-5-methylthiazol Derivatives Containing 1,3,4-Oxadiazole-2-thiol Moiety

Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore 570006, India

Received 26 June 2013; Accepted 17 July 2013

Academic Editors: S. Bellemin-Laponnaz and T. C. Dinadayalane

Copyright © 2013 Kikkeri N. Mohana and Chikkur B. Pradeep Kumar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of new 5-(2-amino-5-methylthiazol-4-yl)-1,3,4-oxadiazole-2-thiol derivatives 6(a–j) were designed and synthesized with various substituted aldehydes. The chemical structures were confirmed by elemental analyses, FT-IR, 1H NMR, and mass spectral studies. The antioxidant activity of the synthesized compounds was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl, nitric oxide, and superoxide radical scavenging assay methods. Compounds 6a, 6e, and 6c showed significant radical scavenging potential due to the presence of electron donating substituent on substituted aldehydes.