Table of Contents
ISRN Biomaterials
Volume 2013 (2013), Article ID 627367, 6 pages
Review Article

Platelet-Rich Fibrin as a Biofuel for Tissue Regeneration

Department of Periodontology, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, Maharashtra 416137, India

Received 17 April 2013; Accepted 20 May 2013

Academic Editors: W.-C. Chen, S. Lamponi, V. Larreta-Garde, and B. Yang

Copyright © 2013 Sujeet Vinayak Khiste and Ritam Naik Tari. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Wound healing is a staged process which involves the activity of leukocytes and platelets. For this process to work efficiently, the platelets play a vital role. The growth factors present in platelets are important to guide the regenerating cells to the area of healing. Platelet-rich-fibrin (PRF) is one such material that holds on to these growth factors enmeshed in the fibrin network resulting in their sustained release over a period of time that can accelerate the wound healing process. With this knowledge, research has been carried out for a past few years for the clinical application of PRF. Various platelet concentrates have been studied including the platelet-rich-plasma (PRP). However, the short duration of cytokine release and its poor mechanical properties have resulted in the search of a new material with adequate properties for clinical application and ease of preparation. PRF has found a place in the regenerative field owing to its advantages over PRP. This review focuses on the properties and various applications of PRF in the clinical practice.