Table of Contents
ISRN Nanotechnology
Volume 2013, Article ID 629510, 5 pages
http://dx.doi.org/10.1155/2013/629510
Review Article

Targeted, Monitored, and Controlled Chemotherapy: A Multimodal Nanotechnology-Based Approach against Cancer

1Department of Medical Physics, Faculty of Medicine, Tehran University of Medical Sciences (TUMS), Tehran 14155-5983, Iran
2School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
3Razi Drug Research Center and Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran

Received 10 May 2013; Accepted 19 July 2013

Academic Editors: A. Hu and A. Taubert

Copyright © 2013 Ali Shakeri-Zadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We review innovative methods for treatment of cancer tumor on the basis of nanotechnology and physics to target, monitor and control release of chemotherapeutic agents. Chemotherapy is one of the main methods of treatment for cancer and plays a vital role in clinical practice, but side effects of anticancer drugs are still critical problems. Magnetic nanoparticles can be applied as an effective drug carriers and contrast agents for magnetic resonance imaging (MRI). Since certain nanoparticles have magnetic properties, they can be trapped in tumor during blood circulation by an external magnetic field. Also, polymeric nanoparticles are great candidates to encapsulate anticancer drugs and to control the release profile of drugs in biologic media. We suggest the construction of drug-loaded polymer-coated magnetic (DPM) nanoplatform with the potential for being utilized in medical imaging as well as having controlled drug release properties. Nanoplatform distribution can be monitored by MRI and with clever combination of ultrasound physics and suggested DPM nanoplatform, it would be feasible to increase the rate of drug release (in situ) and drug uptake by cancerous cell. To optimize the level of drug uptake by cancerous cell, the selection of ultrasound frequency and intensity is essential. The development of suggested method could be a new approach against cancer tumor.